Cognitive# DISORDERS

TRANSLATIONAL MODELS
OF CGNITIVE IMPAIRMENT

Cognitive disorders involve disturbances in information processing and integration associated with cognitive impairment and/or progressive cognitive decline. These disorders can be studied using translational EEG biomarkers that represent powerful assets to assess procognitive or anti-psychotic treatments efficacy.

Applications: Autism spectrum disorders (ASD), Schizophrenia, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Epilepsy

Markers: ERPs, EROs, MMN, Gating, Multisite Coherence

Models: NMDA antagonists, Scopolamine. For other models, please contact us.

Programs: Lead selection (screening of small libraries of compounds), lead validation (dose-response effect, pharmacokinetic), rodent model phenotyping