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  • Digest File

    Drug discovery for Movement DISORDERS

    Most movement disorders in both humans and animals are associated with aberrant oscillatory activities. These activities can be used to objectively and accurately measure diseases, and thus serve as predictive biomarkers for drug discovery. Our solutions will give you reliable evidence, bringing you a step closer to the clinic.

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    Drug discovery for Epileptic DISORDERS

    Spontaneous epileptiform events (spikes, discharges, etc.) are the main features of epileptic disorders, sometimes the only ones. They provide a means to objectively measure the disease; we use them as predictive biomarkers for drug discovery. Our solutions will give you hard evidence, bringing you a step closer to the clinic.

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    Drug discovery for Cognitive DISORDERS

    You design drug candidates to treat brain diseases; we assess their efficacy directly at the source using EEG biomarkers in appropriate rodent models.
    Cognitive impairment/decline in both humans and animals is characterized by perturbations in information processing. The most objective means to assess these disorders is to measure evoked responses using EEG. These responses provide reliable predictive biomarkers for drug discovery, bringing you a step closer to the clinic.

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Posters
from SFN 2015

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    SCIENTIFIC POSTER SFN 2015 – Movement disorders

    Motor symptoms observed in Parkinson’s disease result from a dysfunction of the cortico-basal ganglia circuits mainly due to the death of dopaminergic neurons in the substantia nigra pars compacta.…

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    SCIENTIFIC POSTER SFN 2015 – Cognitive disorders

    Integration and processing of sensory information are altered in a arge number of neurological and psychiatric disorders. One way to study this is to use EEG and more specifically audiotory evoked related potentials (AERPs)…

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Posters
from the MDS Congress 2016

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    Identification of a new biomarker in a mouse model of essential tremor using EEG

    Essential tremor (ET) is one of the most common form of movement disorders. This disorder is characterized by the apparition of postural tremor and intensifies when one tries to use the affected muscles. ET typically involves a tremor of the arms, hands or fingers. The pathophysiology of this disease is not well understood, but recent studies have demonstrated the involvement of the cerebellum and/or olivocerebellar circuits.

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    Improving drug discovery using brain oscillations as biomarkers of Parkinson’s Disease.

    Most movement disorders with a central origin are associated with pathological cortical oscillations, and Parkinson Disease (PD) is among the most prevalent of these disorders. Motor symptoms observed in Parkinson Disease result from a dysfunction of the cortico-basal ganglia circuits mainly due to the death of dopaminergic neurons in the substantia nigra pars compacta.

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