THE MOST ACCURATE TRANSLATIONAL
DRUG DISCOVERY TOOL
Modified electrical activity in neuronal networks is symptomatic of a wide range of CNS disorders. SynapCell’s team has expertise in identifying and deciphering these signals, giving you access to the most accurate translational drug discovery tools.
At SynapCell, we measure the electrical activity of neuronal networks by recording local field potential (LFP). We register different forms of electrical activity, using a range of EEG techniques to give you a precise answer to your specific question.
Various aspects of epileptiform activity can be observed. The two most commonly tracked are epileptiform discharges and epileptic spikes. These two types of brain activity are indicative of hyperexcitability and hypersynchrony in a group of neurons. Both can be measured with EEG across all the structures of the brain.
Useful for: Epilepsy, Autistic spectrum disorders, Alzheimer’s disease. Learn more…
Oscillatory activity is the electrical activity measured in the brain by EEG, whether spontaneous or evoked.
Analysis of this activity is divided into frequency bands to measure the variation in composition and power linked to how the disease and the drugs affect brain function.
This type of activity can also be used to identify the disease state in animal models.
Useful for: Autistic spectrum disorders, Parkinson’s disease, Alzheimer’s disease, Schizophrenia. Learn more…
Event Related Potentials
This type of electrical activity is evoked by a sensory stimulus or changes to the animal’s environment.
Event Related Potentials have a stereotypic structure, composed of a succession of positive and negative voltage deflections over a defined time-scale.
From ERP recordings we can quantify several parameters:
– amplitudes and latencies of deflections,
– sensory gating, which is how the brain filters out redundant information,
– evoked gamma, reflecting the integration and processing of the information in response to sensory stimuli,
– inter-trial coherence (ITC), a measure of the reliability with which a subject responds to each new stimulus.
Useful for: Autistic spectrum disorders, Alzheimer’s disease, Schizophrenia. Learn more…
Multisite coherence reveals the functional cross-talk between at least two connected brain structures. Perturbations to this cross-talk are indicators of the initiation or maintenance of a disease state.
Useful for: Parkinson’s disease, Schizophrenia, Alzheimer’s disease. Learn more…