The GAERS rat a predictive model of absence epilepsy
The GAERS (Genetic Absence Epilepsy Rat from Strasbourg) is a genetic rat model of absence epilepsyABSENCE EPILEPSY is a non-convulsive generalized epilepsy characterized by recurrent episodes of brief unresponsiveness to environmental stimuli, associated on the electroencephalogram (EEG) with bilateral synchronous 3 c/s spike and wave discharges (SWDs). that displays the electroclinical, behavioral and pharmacological features of absence seizures (Danober et al, 1998; Depaulis et van Luijtelaar, 2005).
For the last twenty years, the GAERS has become a gold standard to study the mechanisms underlying absence epilepsy.
- SPONTANEOUS SPIKE-AND-WAVE DISCHARGES
Bilateral generalized SWDs
Frequency : 7-9Hz
Mean duration = 18-25 s
Recurrence = 45-60 SWDs/h at rest
- PHARMACOLOGICAL PREDICTIVITY
Analogy between Human and GAERS pharmacoreactivity
EFFICACY studies
This model offers a very high predictivity and face validity for both anti-absence and aggravating effects of an AED in development.
SAFETY studies
The GAERS rat model is useful to predict adverse and/or pro-absence effects of other drugs targeting the CNS (e.g., anti-psychotic and anxiolytic drugs).
“I believe all potential new AED’s should be assessed in a model like the GAERS model in order to assess their potential for relieving or aggravating absence seizures”
Dr Henrik Klitgaard, Vice President of CNS Research,UCB Pharma SA
