Neuroplasticity Long-term potentiation
Long-term potentiation (LTP) is a long-lasting enhancement in signal transmission that depends on NMDA receptors activation. It represents one of several phenomena underlying synaptic plasticity, the ability of chemical synapses to change their strength.
As memories are thought to be encoded by modification of synaptic strength, LTP is widely considered as one of the major cellular mechanisms that underlies learning and memory. Accordingly, disturbances of LTP are established in psychiatric (e.g. schizophrenia) and neurodegenerative disorders (e.g. Alzheimer’s disease), both including memory impairments.
LTP studies is useful to predict the beneficial or deleterious effects of your compounds on cognition.
Phenotyping of mutant models
To better understand the mechanisms underlying psychiatric or neurodegenerative disorders, mutant mice have been developed during the last ten years.
LTP assessment is the most valuable technique to evaluate cognitive deficiencies in mutant models.
Pharmacology on a schizophrenic mutant model
The KO STOP model, a transgenic mouse with schizophrenic like symptoms, presents a deficiency in LTP, associated with cognitive impairments. This model allows the cognition-related evaluation of your compounds developed for the treatment of schizophrenia.