Acute Acute neurodegenerative disorders such as strokes, traumas, epileptic seizures, spinal cord injuries or chronic Chronic age-related disorders such as Alzheimer’s, Parkinson’s, and Huntington’s diseases and amyotrophic lateral sclerosis
neurodegenerative disorders are mainly induced by endogenous excitotoxins such as glutamate. Moreover, several studies have shown that N-methyl-D-aspartate (NMDA) receptors are the major mediator of excitotoxicity.
SynapCell’s experts measure the functional activity of the hippocampal neuronal network through electrophysiological recordings in excitotoxic conditions. Potential neuroprotective agents were identified, such as antagonists to glutamate receptors (e.g. memantine, MK801) or compounds acting on intracellular pathways (e.g. erythropoietin).
The neuroprotective potential of your compounds is evaluated against glutamate analogs-induced excitotoxicity with:
• Organotypic hippocampal slices: a preserved in vitro neuronal network allowing acute and/or chronic drug incubation
• Customized excitotoxic conditions over a period of hours with glutamate analogs (NMDA, kainate…)
• Multi-electrode arrays: an easy-to-use two-dimensional microelectrode array, providing a functional activity profile of the whole neuronal network