Philippe Kahane, MD, PhD
Neurologist, Professor of Physiology (PU-PH) – Grenoble University Hospital
The scientific activities of Philippe cover various fields in epileptology and physiology in humans : i) characterization of epileptogenic networks using intracerebral recordings and stimulation, ii) assessment of physiological networks by analysing SEEG oscillatory responses to different cognitive, sensorial and motor tasks, iii) implementation of novel surgical therapies such as deep brain stimulation. Peer-reviewed publications: 125 articles in international journals indexed in Medline (H Index: 25).
Philippe is member of the i) editorial boards of Epileptic Disorders (cofounder of the journal) and NCCN Clinical Neurophysiology, ii) scientific council of the French Foundation for Research on Epilepsy (FFRE), the French League against Epilepsy (LFCE) and the French Neurophysiology Society (SNCLF), iii) task-force on Pathology, Invasive evaluation and surgery for cavernoma of the International League Against epilepsy.
Antoine Depaulis, PhD
Director of Research – INSERM – Group Leader and Deputy Director
During the last 20 years, Antoine has developed an expertise in the pathophysiology of epilepsy and the development of animal models. When in Strasbourg, he actively participated in the validation of the Genetic Absence Epilepsy Rat from Strasbourg (GAERS) and he is now in charge of the maintenance of this strain. Using this model and others, he characterized the control of epileptic seizures by the basal ganglia and this concept has led to several clinical validations and applications for neurostimulation. Since his move to Grenoble in 2003, he created a research group composed of clinicians and biologists (n=15) which is dedicated to the understanding of epilepsy and the development of new therapies. In particular, they have developed a new model of mesiotemporal lobe epilepsy in the mouse and have characterized its electroclinical, histological and pharmacological similarities with the human pathology, in collaboration with SynapCell. Antoine has obtained fundings and has coordinated several successful and productive research projects involving colleagues with different expertises.